Essential Biochemistry - Lipid Metabolism (Section 12 - No. 23)
Rate controlling step of cholesterol biosynthesis is:
Squalene → Cholesterol
HMG-CoA → Mevalonic acid → CoA
Acetyl-CoA + Acyl-CoA → HMG-CoA + CoA
Lanosterol → Ergosterol
Explanation
HMG-CoA reductase is the rate-limiting enzyme in cholesterol synthesis.